Kim Mc Arthur

Notable Achievements

Assistant Professor of Biology Kim McArthur presented her research at the annual meeting of the Society for Developmental Biology on July 14, 2021. In her virtual poster, titled “Behavioral Analysis of Respiratory Circuit Development in Larval Zebrafish,” McArthur presented evidence that neural circuits in the brainstem that drive breathing behaviors become functional very early in development, well before they are strictly necessary for oxygen uptake. The larval zebrafish provides a unique opportunity to study the earliest stages in neural circuit development as zebrafish develop outside of their mothers where brain cells can be observed under the microscope using noninvasive methods.

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Expertise

Neuroscience, Developmental Biology, Microscopy

Dr. Kim McArthur is a developmental neurobiologist. As an undergraduate, she attended another awesome liberal arts college (Gustavus Adolphus College in St. Peter, MN), majoring in biology and religion. She earned her Ph.D. in neuroscience from Washington University in St. Louis, then completed post-doctoral work at Cornell University before joining Southwestern as an assistant professor in 2019.

  • Dr. Kim McArthur is a developmental neurobiologist. As an undergraduate, she attended another awesome liberal arts college (Gustavus Adolphus College in St. Peter, MN), majoring in biology and religion. She earned her Ph.D. in neuroscience from Washington University in St. Louis, then completed post-doctoral work at Cornell University before joining Southwestern as an assistant professor in 2019.

  • Students in the McArthur lab investigate the fundamentals of neural circuit development.

    What strategies do neurons use to choose their synaptic partners? How do these partnerships change over time, vary across individuals, and respond to disruptions? What are the consequences for neural circuit function and behavior?

    To answer these questions, we directly and non-invasively explore circuit development as it unfolds in the hindbrain of larval zebrafish, using a powerful combination of approaches — including electrophysiology, neuronal tracing, calcium imaging, and behavior.

  • McArthur KL, Fetcho JR. (2017) Key features of structural and functional organization of zebrafish facial motor neurons are resilient to disruption of neuronal migration. Curr Biol 27: 1746-1756.  PMID: 28602649

    • This research was covered in an interview for The Node.

    Chen S, Chiu CN, McArthur KL, Fetcho JR, Prober DA. (2016) TRP channel mediated neuronal activation and ablation in freely behaving zebrafish. Nat Methods 13: 147-150.  PMID: 26657556

    McArthur KL, Dickman JD. (2011) Behavioral state modulates the activity of brainstem sensorimotor neurons. J Neurosci 31: 16700-16708.  PMID: 22090497

    McArthur KL, Zakir M, Haque A, Dickman JD. (2011) Spatial and temporal characteristics of vestibular convergence. Neuroscience 192: 361-371.  PMID: 21756981

    McArthur KL, Dickman JD. (2011) State-dependent sensorimotor processing: gaze and posture stability during simulated flight in birds. J Neurophysiol 105: 1689-1700.  PMID: 21307332

    McArthur KL, Dickman JD. (2008) Canal and otolith contributions to compensatory tilt responses in pigeons. J Neurophysiol 100: 1488-1497.  PMID: 18632885