Maria Cuevas

Notable Achievements

Professors of Biology Maria Cuevas and Maria Todd received a $12,000 grant from the Joe and Jessie Crump Foundation for Medical Research. The funds will support their current research project titled “Simultaneous Analysis of 84 Tight Junction Genes Involved in Uterine Cancer Progression.” This grant will enable them to expand the scope of their studies and increase the clinical relevance of their research endeavors.

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Expertise

Endocrinology, Biology of Reproduction, Physiology, Tissue Culture Techniques

I came to Southwestern University because I wanted to be part of a dynamic institution in alignment with my passion and enjoyment of learning and education. I see my role as a teacher to challenge my students and prepare them well for whatever postgraduate path they chose. To accomplish this, I have focused on inspiring my students to engage in their studies, to be curious beyond their disciplines, to understand that learning embodies a lifelong process and encouraged them to take ownership for their learning. I believe that we learn from role models as I followed my mother’s and research mentor’s example of perseverance and “take a deep breath” and go for it. Role models may inspire and motivate us, however, it is only when we actually try something that we learn what works and what doesn’t. It is the experience of doing that helps us grow both in our personal and professional lives. Thus, I try to be a model through my passion for biology, by bringing joy and enthusiasm into the classroom, by showing my students not to be afraid of trying new things and to step out of their comfort zone.

Education

PhD, Boston University 1992
MS, Northwestern University 1985
B.S., Purdue University 1982

Honors & Awards

  • Crump Medical Research Foundation Grant (2016)
  • W.M. Keck Undergradaute Education Grant (2014)-Project Director
  • Crump Grant from JP Morgan Foundation for Cancer Research (2014)
  • Sam Taylor Fellowship (2014 and 2012)
  • The Fantra-Love Endowed Fund (2013)
  • ACS Andrew W. Mellon Faculty Renewal Grant (2011)
  • National Science Foundation Major Instrumentation Grant (2009-2012)
  • Andrew W. Mellon Integrated Scholarly Grant (2010-2011)
  • Andrew W. Mellon Integrated Scholarly Grant (2008-2009)
  • JP Morgan Grant (To the Dept. of Biology/Cellular/Molecular BiologyResearchers-2007-2010)
  • Sam Taylor Fellowship (2007)
  • MERCK-AAAS Science Research Grant (Chemistry/Biochemistry and Biology-2004-2007
  • Young Investigator Award, American Association for Clinical Chemistry (1992)
  • Sigma XI Science Award, Boston University Chapter (1991)
  • Graduate Research Award, Boston University (1991)
  • Endocrine Society Summer Fellowship Award (1988)
  • National Hispanic Scholarship Fund (1989)
  • National Consortium for Graduate Degrees in Engineering for Minorities Scholarship (1983-1985)
  • I came to Southwestern University because I wanted to be part of a dynamic institution in alignment with my passion and enjoyment of learning and education. I see my role as a teacher to challenge my students and prepare them well for whatever postgraduate path they chose. To accomplish this, I have focused on inspiring my students to engage in their studies, to be curious beyond their disciplines, to understand that learning embodies a lifelong process and encouraged them to take ownership for their learning. I believe that we learn from role models as I followed my mother’s and research mentor’s example of perseverance and “take a deep breath” and go for it. Role models may inspire and motivate us, however, it is only when we actually try something that we learn what works and what doesn’t. It is the experience of doing that helps us grow both in our personal and professional lives. Thus, I try to be a model through my passion for biology, by bringing joy and enthusiasm into the classroom, by showing my students not to be afraid of trying new things and to step out of their comfort zone.

    Education

    PhD, Boston University 1992
    MS, Northwestern University 1985
    B.S., Purdue University 1982

    Honors & Awards

    • Crump Medical Research Foundation Grant (2016)
    • W.M. Keck Undergradaute Education Grant (2014)-Project Director
    • Crump Grant from JP Morgan Foundation for Cancer Research (2014)
    • Sam Taylor Fellowship (2014 and 2012)
    • The Fantra-Love Endowed Fund (2013)
    • ACS Andrew W. Mellon Faculty Renewal Grant (2011)
    • National Science Foundation Major Instrumentation Grant (2009-2012)
    • Andrew W. Mellon Integrated Scholarly Grant (2010-2011)
    • Andrew W. Mellon Integrated Scholarly Grant (2008-2009)
    • JP Morgan Grant (To the Dept. of Biology/Cellular/Molecular BiologyResearchers-2007-2010)
    • Sam Taylor Fellowship (2007)
    • MERCK-AAAS Science Research Grant (Chemistry/Biochemistry and Biology-2004-2007
    • Young Investigator Award, American Association for Clinical Chemistry (1992)
    • Sigma XI Science Award, Boston University Chapter (1991)
    • Graduate Research Award, Boston University (1991)
    • Endocrine Society Summer Fellowship Award (1988)
    • National Hispanic Scholarship Fund (1989)
    • National Consortium for Graduate Degrees in Engineering for Minorities Scholarship (1983-1985)
  • In collaboration with Dr. Todd, we are studyng the molecular chagnes that lead to the destabilization of tight junctions (structures consisting of a complex of proteins necessary for hte proper function of tissues and organs) and the possible correlation of those changes with cancer development and progression. I have used my expertise in endocrinology and human reproduction to study the effect of estrogen on the expression of the tight junction proteins claudin-3 and -4 in breast and endometrial cancer cell lines; and demonstrated an estrogen-dependent expression and sub-cellular localization of claudins-3 and -4 in both of those cancer cell lines. Currently, our research interest have progressed from studying protein expression levels and localization within the cell to trying to understand how this aberrant changes are involved in the metastasis of breast and endometrial cancer. These two types of cancers are, according to the American Cancer Society, the most common female cancers in the United States.

    As a scientist I believe in a multi-technique approach. I, therefore, have used tissue culture, biochemical analysis and molecular biology techniques to answer the scientific questions at hand. The collaborative nature of these projects have given me the opportunity to learn new techniques and become familiar with concepts in other areas within Biology outside my field of expertise. It is a testament that learning is a life-long process and I hope that by example and through the excitement I convey to my students they too will be passionate about whatever they decide to purse becoming leaders in their chosen field.

  • REPRESENTATIVE PUBLICATIONS

    * = undergraduate author

    Sheller, RA, Cuevas ME and Todd MC. 2017. Comparison of transepithelial resistance measurement techniques: Chopstick vs. Endohm. Biological Proceedings Online

    Cuevas ME, Gaska JM*, Gist AC*, King JM, Sheller RA and Todd MC. 2015. Estrogen-dependent expression and subcellular localization of the tight junction protein claudin-4 in the endometrial HEC-1A cancer cells. Int. J. Oncol. in press

    Cuevas ME and Lindeman TE*. 2015. In vitro cytotoxicity of 4’-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B. Oncology Reports 33:464-470.

    Todd MC, Petty HH, King JM, Pianna-Marshall BN, Sheller RA and Cuevas ME. 2015 Overexpression and delocalization of claudin-3 protein in MCF-7 and MDA-MB_415 breast cancer cell lines. Oncology letters 10:156-162.

    Cuevas, M.E. and Seilheimer, K.* 2008. In vitro cytotoxic activity of anthrapyrazole analogues in human prosate (DU-145) and testicular (NETRA-2) carcinoma cells. Oncology Reports 20:239-244.

    Cuevas, M.E., Collins, K. and Callard, G.V. 1993. Stage-related changes in steroid converting enzyme activities in Squalus testis: Synthesis of biologically active metabolites via 3beta-Hydroxysteroid dehydrogenase/isomerase (3 b -HSD) and 5alpha-reductase. Steroids 58:87-94.

    Cuevas, M.E., Miller, W. and Callard, G.V. 1992. Sulfoconjugation of steroids and the vascular pathway communication in dogfish testis. J. Exp. Zool. 264:119-129.

    Cuevas, M.E. and Callard, G.V. 1992. In vitro steroid secretion by staged-spermatocysts (Sertoli/germ cell units) of dogfish (Squalus acanthias) testis. Gen. Comp. Endo. 88:151-165.

    Cuevas, M.E. and Callard, G.V. 1992. Androgen and progesterone receptors in shark (Squalus) testis: characteristics and stage-related distribution. Endocrinology 130(4):2173-2182.

  • ABSTRACTS AND PRESENTATIONS

    *Denotes collaborative research with undergraduate:

    Cuevas M and Todd M. 2017. Overexpression of claudin-3 tight junction protein in endometrial cancer cell lines and tumor tissues derived from African American women. The 10th American Association of Cancer Research Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Atlanta GA September 25-28. Abstract published in the AACR Meeting Proceedings, nr B67.

    Cuevas M, Gallo M*, Rice K*, Vickers T*, King J, Sheller R and Todd M. 2015. Hormonal Effect on Occludin Expression in the Endometiral Adenocarcinoma HEC-1A and HEC-1B cell lines. The Endocrine Society Annual Meeting, San Diego, CA March 5-8. Abstract was published in the April issue of Endocrine Reviews.

    Petty HM*, King JM, Cuevas ME, Sheller RA and Todd MC. 2013. Effect of claudin-3 protein expression on its sub-cellular localization and cellular motility in breast cancer cell lines. San Antonio Breast Cancer Symposium.

    Sheller RA, Bierwirth NA*, DeLong RL*, Cuevas ME and Todd MC. 2013. Subcellular distribution of claudin-3 in MCF-7 breast cancer cells. American Society for Cell Biology, ASCB 53rd Annual Meeting, New Orleans, LA.

    Cuevas ME, Sheller RA, Holland A*, Piana B* and Todd MC. April 2011. Expression and sub-cellular localization of claudin-4 in MCF-7 breast and HEC-1A endometrial cancer cell lines. Amercian Association for Cancer Resarch, Orlando, FL.

    Sheller RA, Cuevas ME and Todd MC. 2009. Overexpression of claudin-3 in a breast cancer cell line. American Society of Cell Biology. ASCB 49th Annual Conference, San Diego, CA. Poster Published online: http://posters.f1000.com/PosterList?&posterID=31

    Todd MC, Cuevas ME, Piana B* and Sheller RA. April 2009. Overexpression of claudin-3 tight junction protein in MCF-7 and MDA-MB-415 breast cancer cell lines. American Association for Cancer Research, Denver, CO.

    *Seilheimer KC, Guziec FS and Cuevas ME. 2007. Cytotoxicity of anthrapyrazoles (AP-10 and AP-11) on human prostate cancer (DU-145) and testicular cancer (NETRA-2) in culture. Texas Academy of Science: Baylor University, Waco, TX

    *Seilheimer KC, *Boet C, Guziec FS and Cuevas ME. 2007. Cytotoxicity of anthrapyrazoles in various reproductive cancer cell lines. AAAS National Meeting, San Francisco, CA

    *Navaira E and Cuevas ME. 2007. In vitro effects of 4-OH tamoxifen and 17b-estradiol on the human cervical cell line HeLa. Texas Academy of Science: Baylor University, Waco, TX

    *Einem T, *Boet C, Cuevas ME and Foote-Zewail M. 2006. Effects of 4-OH tamoxifen on HEC 1B endometrial cancer cells. AAAS National Meeting, St. Louis, MO.
    *Boet C and Cuevas ME. 2006. Effect of anthrapyrazoles 10 and 11 on human endometrial and mammary adenocarcinoma cells in culture.Texas Academy of Science: Lamar University, Beaumont, TX.