Lynn James Guziec



Assistant Professor

Department of Chemistry

Southwestern University

Georgetown, Texas 78627

(512) 863-1285

guziecl@southwestern.edu





 

Academic Positions:

           
          Southwestern University - Department of Chemistry

                    Assistant  Professor: 1996-

 

          University of Manitoba, Winnipeg, Manitoba, Cananda, Dept. of Pharmacy

                    Visiting Professor, 2004

 

          1998-2003  Contract Synthesis, private biotech company

 

          University of Warwick, Coventry, United Kingdom - Department of Biological Sciences:
                    Visiting Lecturer 1994-1995

 

          New Mexico State University - Department of Chemistry and Biochemistry:        

                    College Assistant Professor 1988-1995

                            --Co-Principal Investigator, National Cancer Institute Contract "Chemical                         
                               Synthesis of Anti-AIDS Compounds" 1991-1994

                            --Principal Assistant, National Cancer Institute Contract "Chemical

                               Synthesis of Anti-AIDS Compounds" 1988-1991




Education:


           Ph.D. in Organic Chemistry, Minor in Biochemistry, Emphasis on Toxicology, May 1988. 
           Department of Chemistry, New Mexico State University, Las Cruces, New Mexico.

           Thesis:  "New Approaches to Tetra-tert-butylethylene: The Tetra-methylcyclobutanedione
           Route; The Sterically Hindered Geminal Dihalide Route."

  

           Masters of Biological Science, December, 1997.  Department of Biological Sciences, University
           of Warwick, Coventry, England Thesis:  "The Derivation of A Short Chemistry Course for First
           Year Biological Students."


           Undergraduate:

           B.A., Special Honors in Chemistry. Cum Laude, Chemistry, 1979.  Russell Sage                             
           College, Troy, New York.




Other Work Experience:

            1987-88        Project Leader, National Cancer Institute,

          Developmental Therapeutics Branch Contract.

            1984-86        Research Assistant in Organic Chemistry.

            1983-85        Contract Synthesis and Development of Specialty Chemicals.

 




Professional Affliations:


            Member of American Chemical Society

                        Rio Grande Valley Section of American Chemical Society 
                        (1991 Chairman ; 1990  Secretary/Treasurer )

            Member of American Association of University Women

            Member of American Registry of Radiologic Technologists

 




Professional Activies:


            Reviewer:

                        Journal of Organic Chemistry

                        Chimiques Belges

 



Awards and Honors:


--Owen Weeks Research Award ­ Outstanding Graduate Student Researcher,
   New Mexico State University, 1986.

            --American Men and Women in Science

 



Publications:


            R. Baechler, L.J. SanFilippo (Guziec) and A. Schroll, "Structural Effects Upon            
            Competetive Decomposition Pathways of Thiosulfoxide Intermediates," Tetrahedron            
            Letters, 22, 5247 (1981).

 

F.S. Guziec, Jr., L.J. SanFilippo (Guziec), C.J. Murphy, C.A. Moustakis and E.R.   
Cullen, "Selones as Intermediates in the Preparation of Extremely Sterically Hindered
Molecules," Tetrahedron, 41, 4873 (1985).

 

F.S. Guziec, Jr. and L.J. SanFilippo (Guziec), "A Convenient Synthesis of   
Sterically Hindered Geminal Dihalides," Synthesis, 547 (1988).

 

            F.S. Guziec, Jr., L.J. SanFilippo (Guziec) and L.M. Wasmund, "Convenient            
            Preparations of Potential Metabolites of 6-n-Propylthiouracil," Org. Prep. Proceed. Int.,            
            22, 619 (1990).

 

            F.S. Guziec, Jr. and L.J. SanFilippo (Guziec), "An Unusual Stereoelectronic            
            Reversal of Reactivities in 2,2,4,4-Tetramethylcyclobutanedione Derivatives," J. Org.            
            Chem., 56, 3178 (1991).

 

             L. J. SanFilippo (Guziec), "An Improved Synthesis of 9-Chloro-2-Methoxyacridine,"             
             Org. Prep. Proced. Int., 23, 130 (1991).

 

K.W. Kohn, A. Orr, P.M. O'Connor, L.J. Guziec and F.S. Guziec, Jr., "Synthesis and
Activity of A Series of Mono­ and Difunctional 9­Aminoacridine Intercalating Mustards,"
Journal of Medicinal Chemistry, 37, 67 (1994).

 

            F.S. Guziec, Jr. and L.J. Guziec,"A Directed Metallation Route to the Selenium            
           Analogue of Methimazole (MMI)," J. Org. Chem., 59, 4691 (1994).

            A. Taurog, M. L. Dorris, L. Guziec and F.S. Guziec Jr., "The Selenium Analog of            
            Methimazole: Measurement of Its Inhibitory Effect on Type I 5'-Deiodinase and of Its            
            Antithyroid Activity," Biochem. Pharmacol.,  48, 1447 (1994).

 

R. Pankayatselvan, F.S. Guziec, Jr., A. Gopalan, L. Guziec, R. Raghavachari and D.
Wei, "Preparation of Some Analogues of Myristoyl CoA," Org. Prep. Proceed. Int.,
27, 347 (1995).

 

            D. F. Mullica, F. S. Guziec Jr.,L.J. Guziec, J.R. Grant, H.J. A. Kautz and J. M.

Farmer, "Synthesis, Characterization, Peripheral Studies and Structural Analysis of
Tri (p-anisyl)selenonium trifluoroacetate," Journal of Molecular Structure,
478, 235-241, (1999).

 

J. Fourie, C.J. Oleschuk, F.S. Guziec, Jr., L. Guziec, D. J. Fiterman, C. Monterrosa and
A. Begleiter, "The Effect of Functional Groups on Reduction and Activation of Quinone
Bioreductive Agents by DT-Diaphorase," Cancer Chemotherapy and Pharmacology,
49, 100-110, (2002).

 

J. Fourie, F. Guziec, Jr., L. Guziec, D.J. Fiterman, C. Monterrosa and A. Begleiter.
³Structure-activity study of benzoquinone bioreductive alkylating agents: Effects on DT-diaphorase
mediated DNA cross-link and strand break formation and relation to mechanisms of cytotoxicity.²
Cancer  Chemother.  Pharmacol., 53, 191-203,( 2004).

 



Invited Chapters:


            F.S. Guziec, Jr. and L.J. SanFilippo (Guziec), "Synthetically Useful Extrusion            
            Reactions of Organic Sulfur, Selenium and Tellurium Compounds," Tetrahedron, 20,            
            6241 (1988).

 

            F.S. Guziec, Jr. and L.J. Guziec, "Synthesis of Functions Containing a            
            Selenocarbonyl or Tellurocarbonyl Group," Organic Functional Group
            Transformations, ed. A.R. Katritzky, Vol. 6, Pergamon Press,1995, pp 587-599. 

 

            F.S. Guziec, Jr.and L.J. Guziec, "Synthesis of Seleno­ and Telluro aldehydes and            
            Ketones," Organic Functional Group Transformations, ed. A.R. Katritzky,Vol. 3,            
            Pergamon Press, 1995, pp. 601-624.

 

            F.S. Guziec, Jr.and L.J. Guziec, "Selenium Extrusion Reactions," in Organoselenium            
            Chemistry: A Practical Approach, ed. T.G. Back, Oxford Press, 1999, pp.193-206.

 

              L. J. Guziec and F. S. Guziec, Jr., "The Synthesis of Seleno- and Telluro-Aldehydes 
and Ketones," in Organic Functional Group Transformations II,  ed. A. R. Katritzky, Elsevier , 
In Press, 2004.

 

              L. J. Guziec and F. S. Guziec, Jr., "The Synthesis of Functions with a Selenocarbonyl
or Tellurocarbonyl Group Organic Functional Group Transformations II,  ed. A. R. Katritzky,  Elsevier,  
In Press, 2004.

             
F. S. Guziec, Jr. and L. J. Guziec, "Multiple Bonds via Extrusion Reactions,"  Organic Reactions, 
In Preparation.