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Herbert and Kate Dishman Professor
of Science
Department of Chemistry
Southwestern University
Georgetown, Texas 78627
(512) 863-1503
FAX (512) 863-1696
guziecf@southwestern.edu
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- Southwestern University.
- Herbert and Kate Dishman Professor of Science,
Department of Chemistry: 1996-
- DeMontfort University, Leicester, United Kingdom.
- Adjunct Professor of Pharmaceutical Sciences: 1995-
- New Mexico State University, Las Cruces, New Mexico.
-Professor of Chemistry: 1990-1996
Sabbatical - 1994-1995 - Dept. of Pharmaceutical
Sciences, DeMontfort University, Leicester,
United Kingdom
-Associate Professor of Chemistry: 1984-1990
-Assistant Professor of Chemistry: 1981-1984
- Tufts University, Medford, MA.
-Assistant Professor: 1977-1981
-Postdoctoral - Department of Chemistry, Wesleyan University,
Middletown, CT, 1976-1977
(Professor Max Tishler)
- Departments of Biology and Chemistry, Massachusetts
Institute of Technology, Cambridge, MA, 1975-1976
(Professor H.G. Khorana)
- Department of Chemistry, Imperial College of Science and
Technology, London, U.K. 1972-1974
(Professor D.H.R. Barton)
-Predoctoral - Department of Chemistry, Massachusetts Institute
of Technology, Ph.D. 1972 NIH Predoctoral Fellowship
(Professor J.C. Sheehan)
-Undergraduate - Loyola University of Chicago, B.S. Honors
Program (Chemistry), Magna cum Laude, 1968
His research interests include:
-- Synthetically useful functionalizing deamination reactions -- Organoselenium Synthesis -- Design and preparation of novel anti-cancer agents -- Sterically hindered molecules
His teaching interests include:
-- Organic Chemistry -- Medicinal Chemistry -- Organic Synthesis -- Spectroscopic Structure Determination -- Consumer Chemistry
Some Recent Representative Publications
F.S. Guziec, Jr. and D. Wei, "Convenient Halodeamination and Hydrodeamination of Primary Amines," J. Org. Chem. 1992, 57, 3772-3776. F.S. Guziec, Jr. and D. Wei, "Base Promoted Oxygenation of N-Substituted-N-Tosylhydrazines - A Convenient Route to Hydroxydeamination of Primary Amines," Tetrahedron Letters, 1992, 33, 7465-7468. L. Collazo, F. S. Guziec, Jr., W.-X. Hu, A. Munoz, D. Wei and M. Alvarado, "Conversion of N-Substituted-N-Sulfonylhydrazines into Hydroperoxides -- A New Synthetic Route to Hydroperoxides via Hydroperoxydeamination," J. Org. Chem., 1993, 58, 6169-6170. L. Collazo, F. S. Guziec, Jr., W.-X. Hu and R. Pankayatselvan "A Convenient Conversion of Primary Amines into the Corresponding Halides-- Radical Promoted Halodeamination via N-Substituted-N-Tosylhydrazines," Tetrahedron Letters, 1994, 35, 7911-7914. L.J. Guziec and F.S. Guziec, Jr."A Directed Metalation Route to the Selenium Analogue of Methimazole, MMI," J. Org. Chem. 1994, 59, 4691-4692. K.W. Kohn, A. Orr, P.M. O'Connor, L.J. Guziec and F.S. Guziec, Jr., "Synthesis and Biological Activity of A Series of Mono and Difunctional 9-Aminoacridine Mustards," J. Med. Chem., 1994, 37, 67-72. A. Taurog, M. L. Dorris, W-X. Hu and F.S. Guziec Jr., "The Selenium Analog of 6-Propylthiouracil: Measurement of Its Inhibitory Effect on Type I 5'-Deiodinase and of Its Antithyroid Activity," Biochem. Pharmacol. 1995, 49, 701-9. T. C. Wong, L. R. Collazo and F. S. Guziec Jr. "14N and 15N NMR Studies of Extremely Sterically Hindered Amines," Tetrahedron, 1995, 51, 649-657. F. S. Guziec, Jr. and L. J. Guziec, "The Synthesis of Selenio- and Tellurio-Aldehydes and Ketones," in Organic Functional Group Transformations, ed. A. R. Katritzky, Vol.3, Pergamon Press, 1995, pp. 601-624. F. S. Guziec, Jr. and L. J. Guziec, "The Synthesis of Functions with a Selenocarbonyl or Tellurocarbonyl Group," in Organic Functional Group Transformations, ed. A. R. Katritzky, Vol.6, Pergamon Press, 1995, pp. 587-599. F. S. Guziec, Jr., "4-(Dimethylamino)pyridinium Chlorochromate," Encyclopedia of Reagents for Organic Synthesis, Vol. 3 (L. Paquette, ed.), 2024-2025, Wiley, 1996. F. S. Guziec, Jr. and L. J. Guziec, "Selenium Extrusion Reactions," in Organoselenium Chemistry: A Practical Approach, ed. T.G.Back, Oxford University Press, 1998. In Press