Dr. Frank Guziec

Dr. Frank S. Guziec Jr.

Herbert and Kate Dishman Professor of Science
Department of Chemistry
Southwestern University
Georgetown, Texas 78627
(512) 863-1503
FAX (512) 863-1696
guziecf@southwestern.edu

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Academic Positions:



- Southwestern University.
	- Herbert and Kate Dishman Professor of Science,
		Department of Chemistry: 1996-
- DeMontfort University, Leicester, United Kingdom. 
	- Adjunct Professor of Pharmaceutical Sciences:  1995-
- New Mexico State University, Las Cruces, New Mexico.
	 -Professor of Chemistry: 1990-1996
	   	Sabbatical - 1994-1995 - Dept. of Pharmaceutical
                Sciences, DeMontfort  University, Leicester,
                United Kingdom 
	 -Associate Professor of Chemistry: 1984-1990
	 -Assistant Professor of Chemistry:  1981-1984
- Tufts University, Medford, MA.
	 -Assistant Professor:  1977-1981
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Education:



-Postdoctoral 	- Department of Chemistry, Wesleyan University, 
			  Middletown, CT, 1976-1977
			  (Professor Max Tishler)  
        	- Departments of Biology and Chemistry, Massachusetts
		  Institute of Technology, Cambridge,  MA, 1975-1976
		  (Professor H.G. Khorana)
		- Department of Chemistry, Imperial College of Science and
		  Technology, London,  U.K. 1972-1974  
		  (Professor D.H.R. Barton)
  
-Predoctoral  	- Department of Chemistry, Massachusetts Institute
		   of Technology, Ph.D. 1972 NIH Predoctoral Fellowship
		  (Professor J.C. Sheehan)

-Undergraduate  - Loyola University of Chicago, B.S. Honors
		  Program (Chemistry), Magna cum Laude, 1968


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His research interests include:

-- Synthetically useful functionalizing deamination reactions -- Organoselenium Synthesis -- Design and preparation of novel anti-cancer agents -- Sterically hindered molecules
His teaching interests include:

-- Organic Chemistry -- Medicinal Chemistry -- Organic Synthesis -- Spectroscopic Structure Determination -- Consumer Chemistry


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Some Recent Representative Publications


	F.S. Guziec, Jr. and D. Wei, "Convenient Halodeamination  and
	Hydrodeamination of Primary Amines,"  J. Org. Chem. 1992, 57, 3772-3776.

	F.S. Guziec, Jr. and D. Wei, "Base Promoted Oxygenation of
	N-Substituted-N-Tosylhydrazines - A Convenient Route to Hydroxydeamination
	of Primary Amines," Tetrahedron Letters, 1992, 33, 7465-7468.

	 L. Collazo, F. S. Guziec, Jr., W.-X. Hu, A. Munoz, D. Wei and
	M. Alvarado, "Conversion of N-Substituted-N-Sulfonylhydrazines into
	Hydroperoxides -- A New Synthetic Route to Hydroperoxides via
	Hydroperoxydeamination," J. Org. Chem., 1993, 58, 6169-6170.

	L. Collazo, F. S. Guziec, Jr., W.-X. Hu and R. Pankayatselvan
	"A Convenient Conversion of Primary Amines into the Corresponding Halides--
	Radical Promoted Halodeamination via N-Substituted-N-Tosylhydrazines,"
	Tetrahedron Letters, 1994, 35,  7911-7914.

 	L.J. Guziec and F.S. Guziec, Jr."A Directed Metalation Route to
	the Selenium Analogue of Methimazole, MMI," J. Org. Chem. 1994, 59,
	4691-4692.

	K.W. Kohn, A. Orr, P.M. O'Connor, L.J. Guziec and F.S. Guziec,
	Jr., "Synthesis and Biological Activity of A Series of Mono and
	Difunctional 9-Aminoacridine Mustards," J. Med. Chem., 1994, 37, 67-72.

	A. Taurog, M. L. Dorris, W-X. Hu and F.S. Guziec Jr., "The
	Selenium Analog of 6-Propylthiouracil: Measurement of Its Inhibitory
	Effect on Type I 5'-Deiodinase and of Its Antithyroid Activity,"
	Biochem. Pharmacol. 1995, 49, 701-9.

	T. C. Wong, L. R. Collazo and F. S. Guziec Jr. "14N and 15N NMR
	Studies of Extremely Sterically Hindered Amines," Tetrahedron, 
	1995, 51, 649-657.

 	F. S. Guziec, Jr. and L. J. Guziec, "The Synthesis of Selenio- and
	Tellurio-Aldehydes and Ketones," in Organic Functional Group
	Transformations,  ed. A. R. Katritzky, Vol.3, Pergamon Press,  
	1995, pp. 601-624.

	F. S. Guziec, Jr. and L. J. Guziec, "The Synthesis of Functions
	with a Selenocarbonyl or Tellurocarbonyl Group," in Organic Functional
	Group Transformations,  ed. A. R. Katritzky, Vol.6, Pergamon Press,
	1995, pp. 587-599.

	F. S. Guziec, Jr., "4-(Dimethylamino)pyridinium
	Chlorochromate,"
	Encyclopedia of Reagents for Organic Synthesis,  Vol. 3 (L. Paquette,
	ed.), 2024-2025,  Wiley, 1996.

	 F. S. Guziec, Jr. and L. J. Guziec,  "Selenium Extrusion
	Reactions,"   in Organoselenium Chemistry: A Practical Approach,  ed.
	T.G.Back, Oxford University Press, 1998. In Press

This page created and maintaned by Daniel Guziec,
last updated fri. 7/31/1998 1:13 PM